I will put some samples about this. ( when i get the time)
First of all we need the program i said before.Fireworks mx( the one I use).
Now, the first thing I do when making a comic is to start in getting the sprites of the game and backgrounds.
( try by google, yahoo or another with (game name plus sprite-sheet )
Warining never forget: Make a Script so you can check all the time about the history and dont need make something again over again.
Step1
Make with your new document a 800x200 rectangle.
( By the way you can add borders or not (frameworks to separate the parts of each one)
Step2
Now You need decide what background will be in ( that depends on how your story starts)
Step 3
At this point you need to know what chars you will use and according to the action put them in each part of the image.
Step4
Well about what yo wrote in the script before you will put the dialogues but you need to count the size of the sprite char (acording at the place depende if you make it bigger or small).So lets strench their height and witdh.
Step5
Like we said "before you have the chars nice look at this--> you want them seeing each other and talking or moving (that depend about your script ).
Step6
You ask why a big space? well thats because we need a good looking background the char size need to be at your point ( what i mean get the taller as the rbo game : D ) and the place we have left for the dialogue.
Step7
Well more people who have this sprites about mouths in rbo can copy them and put in the char so it will show like it s talking and saying his/her dialogue.
Step8
Now let s put the dialogue in box of text so can show the dialogue of each char.
Attention :-->don t let the text box be ver bigger get a font that can look little but you and others can see : D.
step9
Well we have the text box made. What you have to do now is put the text box close to the speaker you choosed. not on him/her or anything only close but without loosing the image.
step10
ok we are close to finish, you can centering the text in the text boxes. and there you have a webcomic with sprites.
step 11
Check if you did all ok and you like the little 4 images comic you made.
well i will add some samples when i get the time so you can see. : D.